Analysis Results

              

            

            

              

                
Modified Dixon Up-and-Down Method

                

                  The modified Dixon sequential (up-and-down) method is a dose-finding strategy: 
                  if the previous case is effective, the next case receives a lower dose; 
                  if the previous case is ineffective, the next case receives a higher dose. 
                  After obtaining multiple "effective ↔ ineffective" transition points, 
                  the ED
                  50
                   and its 95% confidence interval are calculated.
                

                

                  This is the mainstream approach in anesthetic clinical pharmacology research 
                  for determining the ED
                  50
                   of sedation, induction, or suppression responses.
                

                

                
Probit Regression

                

                  A generalized linear model with a probit link function is fitted to the binary 
                  effect data (0 = ineffective, 1 = effective) against dose. 
                  The model estimates the dose-response relationship and allows calculation of 
                  any ED value (e.g., ED
                  50
                  , ED
                  95
                  ) 
                  along with 95% confidence intervals using the delta method (MASS::dose.p).